Everton have already been knocked out of the competition, but that will not stop them from trying to put on a show for the Goodison Park faithful to enjoy.
A dismal start to the campaign saw the Toffees lose three out of four matches, including a 3-0 defeat by group leaders Atalanta in the reverse fixture in September.
The Italians are locked with Lyon on eight points at the top of the group and will look for an away win in the competition for the first time since the 1990/91 UEFA Cup.
Phil Jagielka and Mason Holgate miss out through injury, while Morgan Schneiderlin is suspended and Oumar Niasse is ineligible.
Everton v Atalanta potential lineups:
Everton: Pickford; Kenny, Keane, Williams, Martina; Besic, Davies, Lookman, Klaassen, Rooney; Calvert-Lewin.
Atalanta: Berisha; Palomino, Caldara, Masiello; Castagne, de Roon, Freuler, Cristante, Hateboer; Petagna, Gomez.