Jurgen Klopp's side are back in the Champions League for the first time since 2014/15 and will come up against Maribor and Spartak Moscow, as well as Sevilla in Group E.
The major news ahead of the clash is that Philippe Coutinho, whose Anfield future had been in doubt all summer amid interest from Barcelona, could make an appearance for Liverpool.
However, Mohamed Salah is unlikely to start at Anfield given that he missed training on Tuesday due to illness.
Deadline day signing Alex Oxlade-Chamberlain will certainly be in contention for a place in the starting XI and Sadio Mane will also be available as his three-match been is only active in domestic competitions.
Sevilla will be going into the game with the knowledge that they outplayed the Reds in the Europa League final in 2016, running out 3-1 winners on that occasion.
Nolito and Johannes Geis are both sideline for the visitors with injuries, while goalkeeper David Soria is also a concern.
Possible lineups:
Liverpool: Karius, A. Arnold, Lovren, Matip, Moreno, Henderson, Can, Oxlade-Chamberlain, Firmino, Coutinho, Mane
Sevilla: Rico, Mercado, Kjaer, Lenglet, Escudero, N'Zonzi, Pizarro, Banega, Navas, Ben Yedder, Correa