Arsenal:
Sead Kolasinac and Alexandre Lacazette were rested for the midweek draw against West Ham and are therefore likely to return for this encounter.
Arsene Wenger will, however, be without Aaron Ramsey and Theo Walcott, who are sidelined with a hamstring and groin problem respectively.
Newcastle:
Despite a winless run of eight games (D1, L7), club captain Jamaal Lascelles isn't panicking just yet.
"A lot of people would probably have been happy with the points we are on if they were asked at the start of the season, so I am not going to say we are in a relegation battle."
Rafa Benitez will be without Jonjo Shelvey after he picked up a red card in Wednesday night's 1-0 home defeat by Everton.
Aleksandar Mitrovic will also sit out with a back problem, but full-back Paul Dummett could return after recovering from a hamstring injury.
Recent form:
Possible lineups:
Arsenal: Cech, Bellerin, Koscielny, Monreal, Kolasinac, Elneny, Wilshere, Welbeck, Ozil, Sanchez, Lacazette.
Newcastle: Darlow, Yedline, Lascelles, Lejeune, Manquillo, Perez, Merino, Ritchie, Diame, Atsu, Gayle.