The Welshman will lead the line alongside Cristiano Ronaldo at the Bernabeu as Real look to defend their 3-0 lead from the first leg to progress to the semi-finals for the eighth season in a row.
Keylor Navas starts in goal, behind Dani Carvajal, Raphael Varane, Jesus Vallejo - in for the suspended Sergio Ramos - and Marcelo.
Zinedine Zidane has once again opted to play a diamond in midfield with Casemiro anchoring the engine room behind Toni Kroos and Luka Modric, with Isco at the tip.
April 11, 2018
The visitors meanwhile have made several changes to the team that started last week's defeat.
Gianluigi Buffon is the man between the sticks, with Mateo De Sciglio, Medhi Benatia, Giorgio Chiellini and Alex Sandro at the back.
Sami Kedira, Miralem Pjanic and Blaise Matudi make up the engine room, with Douglas Costa, Gonzalo Higuain and Mario Mandzukic charged with providing the bulk of the attacking threat.
April 11, 2018